Determining Physical Mechanisms of Gene Expression Regulation from Single Cell Gene Expression Data
نویسندگان
چکیده
منابع مشابه
Determining Physical Mechanisms of Gene Expression Regulation from Single Cell Gene Expression Data
Many genes are expressed in bursts, which can contribute to cell-to-cell heterogeneity. It is now possible to measure this heterogeneity with high throughput single cell gene expression assays (single cell qPCR and RNA-seq). These experimental approaches generate gene expression distributions which can be used to estimate the kinetic parameters of gene expression bursting, namely the rate that ...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2016
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1005072